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PHACTR4
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. Belongs to the phosphatase and actin regulator family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Phosphatase |
| Chromosomal Location of mouse Ortholog: 4|4 D2.3 |
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Cellular Component:
cell projection; cytoplasm; lamellipodium
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Molecular Function:
actin binding; protein phosphatase 1 binding; protein phosphatase activator activity; protein phosphatase inhibitor activity
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Biological Process:
actin cytoskeleton organization; closure of optic fissure; enteric nervous system development; multicellular organism development; negative regulation of integrin-mediated signaling pathway; nervous system development; neural crest cell migration; neural tube closure; positive regulation of catalytic activity; regulation of cell cycle; Rho protein signal transduction
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Reference #:
Q501J7
(UniProtKB)
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Alt. Names/Synonyms: 3110001B12Rik; AI527228; AW495572; C330013F19Rik; FLJ13171; Humdy; Kiaa4120; mKIAA4120; N28169; OTTMUSP00000010123; Phactr4; PHAR4; Phosphatase and actin regulator 4; Protein Humpty dumpty
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Gene Symbols: Phactr4
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Molecular weight:
76,632 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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