CTNNA1 Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Belongs to the vinculin/alpha-catenin family. Expressed ubiquitously in normal tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18 B1|18 18.89 cM
Cellular Component:  acrosomal vesicle; actin cytoskeleton; adherens junction; catenin complex; cell junction; cell-cell adherens junction; cell-cell junction; cytoplasm; cytoskeleton; cytosol; flotillin complex; Golgi apparatus; intercalated disc; intracellular membrane-bounded organelle; lamellipodium; membrane; plasma membrane; zonula adherens
Molecular Function:  actin filament binding; beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; protein binding; protein heterodimerization activity; structural molecule activity; vinculin binding
Biological Process:  actin filament organization; apical junction assembly; cell adhesion; cellular protein localization; cellular response to indole-3-methanol; epithelial cell-cell adhesion; establishment or maintenance of cell polarity; gap junction assembly; negative regulation of apoptotic process; negative regulation of cell motility; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of integrin-mediated signaling pathway; negative regulation of neuroblast proliferation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of smoothened signaling pathway; protein heterooligomerization; regulation of cell proliferation
Reference #:  P26231 (UniProtKB)
Alt. Names/Synonyms: 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI988031; alpha E catenin; Alpha E-catenin; alpha(E)-catenin; cadherin associated protein; CAP102; Cat; catenin (cadherin associated protein), alpha 1; catenin alpha 1; Catenin alpha-1; Catna1; CTNA1; Ctnna1
Gene Symbols: Ctnna1
Molecular weight: 100,106 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene