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B-Myc
Seems to act as an inhibitor of cellular proliferation. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of mouse Ortholog: 2|2 A3 |
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Cellular Component:
chromatin; Myc-Max complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex; spindle
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Molecular Function:
core promoter sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; molecular adaptor activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; SCF ubiquitin ligase complex binding; transcription coregulator binding
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Biological Process:
cellular response to hypoxia; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; DNA damage response; ERK1 and ERK2 cascade; G1/S transition of mitotic cell cycle; intracellular iron ion homeostasis; MAPK cascade; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; protein-DNA complex disassembly; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of telomere maintenance; response to gamma radiation
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Reference #:
Q6P8Z1
(UniProtKB)
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Alt. Names/Synonyms: 2900002K07Rik; AW060705; B-Myc; Bmyc; brain expressed myelocytomatosis oncogene; Mycb; OTTMUSP00000013515; Protein B-Myc
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Gene Symbols: Bmyc
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Molecular weight:
18,526 Da
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Basal Isoelectric point:
4.28
Predict pI for various phosphorylation states
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