FLN29 Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component: 
Molecular Function:  metal ion binding; protein binding; zinc ion binding
Biological Process:  negative regulation of innate immune response
Reference #:  Q3UDK1 (UniProtKB)
Alt. Names/Synonyms: 1110008K06Rik; Fln; Fln29; FLN29 gene product; Protein FLN29; TRAD1; TRAF type zinc finger domain containing 1; TRAF-type zinc finger domain-containing protein 1; Trafd1
Gene Symbols: Trafd1
Molecular weight: 64,283 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
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FLN29

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene