TPM3 a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Motor; Oncoprotein
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  actin cytoskeleton; actin filament; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; growth cone; neuron projection; podosome; stress fiber
Molecular Function:  actin binding; actin filament binding; protein binding
Biological Process:  actin filament organization
Reference #:  P21107 (UniProtKB)
Alt. Names/Synonyms: gamma-TM; Gamma-tropomyosin; hTM30nm; hTMnm; MGC102590; skalphaTM.2; Tm5NM; Tpm-5; Tpm3; Tpm5; Trop-5; tropomyosin 3, gamma; tropomyosin 5; Tropomyosin alpha-3 chain; Tropomyosin-3
Gene Symbols: Tpm3
Molecular weight: 32,994 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene