DAB2 an adaptor protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Involved in several receptor-mediated signaling pathways. Required for recycling of the TGF-beta receptor. Involved in endocytosis of CFTR and of megalin/LRP2 lipoprotein receptor during embryonal development. Interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Three alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Tumor suppressor
Chromosomal Location of mouse Ortholog: 15 A1|15 2.15 cM
Cellular Component:  apical plasma membrane; clathrin coat of coated pit; clathrin-coated pit; clathrin-coated vesicle; clathrin-coated vesicle membrane; cytoplasm; cytoplasmic vesicle; fibrillar center; intracellular membrane-bounded organelle; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  AP-2 adaptor complex binding; cargo receptor activity; clathrin adaptor activity; clathrin binding; integrin binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein C-terminus binding; SMAD binding
Biological Process:  activation of JUN kinase activity; apoptotic process; cell differentiation; cell morphogenesis involved in differentiation; cellular response to epidermal growth factor stimulus; cellular response to transforming growth factor beta stimulus; clathrin coat assembly; endocytosis; endoderm development; excretion; in utero embryonic development; leading edge cell differentiation; multicellular organism development; myeloid cell differentiation; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron projection development; negative regulation of protein binding; negative regulation of protein localization to plasma membrane; negative regulation of transcription, DNA-templated; pinocytosis; positive regulation of aldosterone biosynthetic process; positive regulation of aldosterone secretion; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of clathrin-dependent endocytosis; positive regulation of early endosome to late endosome transport; positive regulation of endocytosis; positive regulation of epithelial to mesenchymal transition; positive regulation of integrin-mediated signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of receptor recycling; positive regulation of SMAD protein signal transduction; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; protein transport; receptor-mediated endocytosis; regulation of Rho-dependent protein serine/threonine kinase activity; response to steroid hormone; Wnt signaling pathway
Reference #:  P98078 (UniProtKB)
Alt. Names/Synonyms: 5730435J12Rik; AA960054; Adaptor molecule disabled-2; AI957090; D15Wsu122; D15Wsu122e; D630005B22Rik; Dab2; Differentially expressed in ovarian carcinoma 2; disabled 2, mitogen-responsive phosphoprotein; Disabled homolog 2; disabled homolog 2 (Drosophila); DOC-2; Doc2; Mitogen-responsive phosphoprotein; p96
Gene Symbols: Dab2
Molecular weight: 82,312 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DAB2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene