APPL Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages. Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways. Required for fibroblast migration through HGF cell signaling. Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex. High levels in heart, ovary, pancreas and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 14|14 A3
Cellular Component:  cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; early phagosome; endosome; endosome membrane; intracellular vesicle; macropinosome; membrane; nucleus; plasma membrane; ruffle; vesicle membrane
Molecular Function:  beta-tubulin binding; identical protein binding; phosphatidylinositol binding; phosphatidylserine binding; protein binding; protein homodimerization activity; protein kinase B binding; protein-containing complex binding
Biological Process:  adiponectin-activated signaling pathway; cell cycle; cell proliferation; cellular response to hepatocyte growth factor stimulus; insulin receptor signaling pathway; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of cytokine production involved in inflammatory response; positive regulation of glucose import; positive regulation of macropinocytosis; positive regulation of melanin biosynthetic process; protein import into nucleus; regulation of fibroblast migration; regulation of glucose import; regulation of innate immune response; regulation of protein localization to plasma membrane; regulation of toll-like receptor 4 signaling pathway; signaling; transforming growth factor beta receptor signaling pathway
Reference #:  Q8K3H0 (UniProtKB)
Alt. Names/Synonyms: 2900057D21Rik; 7330406P05Rik; Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AI585782; APPL; Appl1; AW209077; BB022931; C88264; DCC-interacting protein 13-alpha; DIP13; DIP13 alpha; Dip13-alpha; Dip13a; DP13A; Kiaa1428; OTTMUSP00000017569
Gene Symbols: Appl1
Molecular weight: 79,328 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA