ZNF148 a transcription factor. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16 B3|16 23.93 cM
Cellular Component:  Golgi apparatus; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  gamete generation; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly
Reference #:  Q61624 (UniProtKB)
Alt. Names/Synonyms: 2210405J08Rik; AI480666; AW045217; BERF-1; Beta enolase repressor factor 1; BFCOL1; G-rich box-binding protein; Transcription factor BFCOL1; Transcription factor ZBP-89; ZBP-89; Zbp89; Zfp148; Zinc finger DNA-binding protein 89; Zinc finger protein 148; ZN148; Znf148
Gene Symbols: Znf148
Molecular weight: 88,751 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene