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PTH2R
This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family. Expressed abundantly in brain and pancreas. Also expressed in the testis. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 2q34 |
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Cellular Component:
plasma membrane
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Molecular Function:
G protein-coupled peptide receptor activity; parathyroid hormone receptor activity; peptide hormone binding; protein binding
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Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of cold-induced thermogenesis
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Reference #:
P49190
(UniProtKB)
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Alt. Names/Synonyms: Parathyroid hormone 2 receptor; parathyroid hormone receptor 2; PTH2 receptor; PTH2R; PTHR2
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Gene Symbols: PTH2R
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Molecular weight:
62,236 Da
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Basal Isoelectric point:
6.65
Predict pI for various phosphorylation states
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