PTH2R This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family. Expressed abundantly in brain and pancreas. Also expressed in the testis. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 2q34
Cellular Component:  plasma membrane
Molecular Function:  G protein-coupled peptide receptor activity; parathyroid hormone receptor activity; peptide hormone binding; protein binding
Biological Process:  adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of cold-induced thermogenesis
Reference #:  P49190 (UniProtKB)
Alt. Names/Synonyms: Parathyroid hormone 2 receptor; parathyroid hormone receptor 2; PTH2 receptor; PTH2R; PTHR2
Gene Symbols: PTH2R
Molecular weight: 62,236 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene