PCOLCE2 Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q23
Cellular Component:  extracellular region
Molecular Function:  collagen binding; heparin binding; peptidase activator activity
Biological Process:  cellular response to leukemia inhibitory factor; positive regulation of peptidase activity
Reference #:  Q9UKZ9 (UniProtKB)
Alt. Names/Synonyms: PCOC2; PCOLCE2; PCPE-2; PCPE2; Procollagen C-endopeptidase enhancer 2; Procollagen C-proteinase enhancer 2; Procollagen COOH-terminal proteinase enhancer 2
Gene Symbols: PCOLCE2
Molecular weight: 45,717 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene