JTV1
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Translation; Translation regulation |
Chromosomal Location of human Ortholog: 7p22.1 |
Cellular Component:
aminoacyl-tRNA synthetase multienzyme complex; cytosol; nucleus
|
Molecular Function:
molecular adaptor activity; protein binding
|
Biological Process:
apoptotic process; negative regulation of cell population proliferation; positive regulation of protein ubiquitination; protein ubiquitination; protein-containing complex assembly; translation; type II pneumocyte differentiation
|
Disease: Leukodystrophy, Hypomyelinating, 17
|
Reference #:
Q13155
(UniProtKB)
|
Alt. Names/Synonyms: AIMP2; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthetase complex interacting multifunctional protein 2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; ARS-interacting multi-functional protein 2; HLD17; JTV-1; JTV1; Multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; P38; PRO0992; Protein JTV-1
|
Gene Symbols: AIMP2
|
Molecular weight:
35,349 Da
|
Basal Isoelectric point:
8.45
Predict pI for various phosphorylation states
|