NCAM-L1 Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq37
Cellular Component:  axon; axonal growth cone; cell surface; dendrite; dendritic growth cone; endosome; external side of plasma membrane; integral component of membrane; membrane; membrane raft; neuronal cell body; plasma membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; terminal bouton
Molecular Function:  axon guidance receptor activity; identical protein binding; integrin binding; PDZ domain binding; protein binding; protein domain specific binding; protein self-association; sialic acid binding
Biological Process:  axon development; axon guidance; axonal fasciculation; cell migration; cell surface receptor signaling pathway; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cellular response to dexamethasone stimulus; cellular response to ethanol; cellular response to nerve growth factor stimulus; cellular response to thyroxine stimulus; cellular response to transforming growth factor beta stimulus; dopaminergic neuron differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; homotypic cell-cell adhesion; leukocyte cell-cell adhesion; modulation of chemical synaptic transmission; neuron differentiation; neuron projection development; positive regulation of axon extension; positive regulation of calcium-mediated signaling; positive regulation of cell-cell adhesion; positive regulation of cell-substrate adhesion; regulation of ERK1 and ERK2 cascade; response to activity; response to thyroid hormone; synapse organization
Reference #:  Q05695 (UniProtKB)
Alt. Names/Synonyms: Caml1; Hsas; Hyd; L1 cell adhesion molecule; L1cam; N-CAM L1; N-CAM-L1; NCAM-L1; NCAML1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NILE
Gene Symbols: L1cam
Molecular weight: 140,935 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene