NCAM-L1 cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component:  axon; axonal growth cone; cell surface; dendrite; integral component of membrane; neuronal cell body; plasma membrane
Molecular Function:  protein binding; protein domain specific binding
Biological Process:  axon development; axon guidance; cell adhesion; cell migration; cell-matrix adhesion; chemotaxis; leukocyte migration; nervous system development; neuron projection development; positive regulation of axon extension; synapse organization
Disease: Corpus Callosum, Partial Agenesis Of, X-linked; Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius; Masa Syndrome
Reference #:  P32004 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody R1; CAML1; CD171; HSAS; HSAS1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; Neural cell adhesion molecule L1; S10; SPG1
Gene Symbols: L1CAM
Molecular weight: 140,003 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NCAM-L1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein