TR-alpha iso3 Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 11 D|11 62.58 cM
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  chromatin DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; intronic transcription regulatory region DNA binding; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; protein dimerization activity; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; single-stranded RNA binding; steroid hormone receptor activity; steroid receptor RNA activator RNA binding; TBP-class protein binding; thyroid hormone binding; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  animal organ morphogenesis; brain development; cartilage condensation; cell differentiation; cytoplasmic sequestering of transcription factor; erythrocyte differentiation; female courtship behavior; hormone-mediated signaling pathway; learning or memory; multicellular organism development; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription, initiation; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; ossification; positive regulation of canonical Wnt signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of female receptivity; positive regulation of myotube differentiation; positive regulation of transcription by RNA polymerase II; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptotic process; regulation of thyroid hormone mediated signaling pathway; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to cold; response to lipid; thyroid gland development; thyroid hormone mediated signaling pathway; transcription by RNA polymerase II; type I pneumocyte differentiation
Reference #:  P63058-3 (UniProtKB)
Alt. Names/Synonyms: 6430529J03Rik; AW259572; c-erbA-1; C-erba-alpha; c-erbAalpha; Erba; Nr1a1; Nuclear receptor subfamily 1 group A member 1; OTTMUSP00000006788; Rvr; T3R[a]; T3Ralpha; THA; Thra; Thra1; Thra2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2
Gene Symbols: Thra
Molecular weight: 50,954 Da
Basal Isoelectric point: 7.13  Predict pI for various phosphorylation states
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TR-alpha iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA