TR-alpha Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of human Ortholog: 17q21.1
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; general transcription initiation factor binding; nuclear receptor activity; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; TBP-class protein binding; thyroid hormone binding; transcription cis-regulatory region binding; zinc ion binding
Biological Process:  cartilage condensation; cell differentiation; erythrocyte differentiation; female courtship behavior; hormone-mediated signaling pathway; learning or memory; negative regulation of DNA-templated transcription; negative regulation of DNA-templated transcription initiation; negative regulation of RNA polymerase II transcription preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; ossification; positive regulation of cold-induced thermogenesis; positive regulation of female receptivity; positive regulation of transcription by RNA polymerase II; regulation of heart contraction; regulation of lipid catabolic process; regulation of myeloid cell apoptotic process; regulation of thyroid hormone mediated signaling pathway; regulation of transcription by RNA polymerase II; response to cold; thyroid gland development; thyroid hormone mediated signaling pathway; transcription by RNA polymerase II; type I pneumocyte differentiation
Disease: Hypothyroidism, Congenital, Nongoitrous, 6
Reference #:  P10827 (UniProtKB)
Alt. Names/Synonyms: AR7; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog; c-erbA-1; c-erbA-alpha; CHNG6; EAR-7; EAR7; ERB-T-1; ERBA; ERBA-related 7; ERBA1; MGC000261; MGC43240; NR1A1; Nuclear receptor subfamily 1 group A member 1; THA; THRA; THRA1; THRA2; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR-alpha; triiodothyronine receptor; V-erbA-related protein 7
Gene Symbols: THRA
Molecular weight: 54,816 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein