MAX Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Belongs to the MAX family. High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of rat Ortholog: 6q24
Cellular Component:  chromatin; dendrite; Mad-Max complex; MLL1 complex; Myc-Max complex; nucleus; PML body; protein-DNA complex; RNA polymerase II transcription regulator complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; identical protein binding; nucleic acid binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  cellular response to peptide hormone stimulus; cellular response to starvation; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; neuron apoptotic process; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to axon injury; response to insulin; response to organonitrogen compound; retina development in camera-type eye
Reference #:  P52164 (UniProtKB)
Alt. Names/Synonyms: Max; MGC124611; MYC associated factor X; Myc-associated factor X; Protein max
Gene Symbols: Max
Molecular weight: 18,272 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MAX

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene