PFKP Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other
Chromosomal Location of mouse Ortholog: 13|13 A1
Cellular Component:  6-phosphofructokinase complex; cytoplasm; cytosol; membrane
Molecular Function:  6-phosphofructokinase activity; AMP binding; ATP binding; catalytic activity; fructose-6-phosphate binding; identical protein binding; kinase activity; metal ion binding; monosaccharide binding; nucleotide binding; protein-containing complex binding; transferase activity
Biological Process:  canonical glycolysis; cellular response to leukemia inhibitory factor; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glucose catabolic process; glycolytic process; glycolytic process through fructose-6-phosphate; metabolic process; phosphorylation; protein homotetramerization
Reference #:  Q9WUA3 (UniProtKB)
Alt. Names/Synonyms: 1200015H23Rik; 6-phosphofructokinase type C; 9330125N24Rik; ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; ATP:D-fructose 6-phosphate 1-phosphotransferase; K6PP; PFK-; PFK-C; PFK-P; PFKAP; Pfkc; Pfkp; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphohexokinase
Gene Symbols: Pfkp
Molecular weight: 85,455 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene