UTX Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Belongs to the UTX family. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of mouse Ortholog: X A1.2-A1.3|X 13.45 cM
Cellular Component:  histone methyltransferase complex; MLL3/4 complex; nucleus
Molecular Function:  chromatin binding; chromatin DNA binding; dioxygenase activity; histone demethylase activity (H3-K27 specific); identical protein binding; metal ion binding; oxidoreductase activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  canonical Wnt signaling pathway; cardiovascular system development; chromatin organization; chromatin remodeling; embryonic organ development; heart development; heart morphogenesis; histone H3-K27 demethylation; in utero embryonic development; mesodermal cell differentiation; multicellular organism growth; neural tube closure; neural tube development; notochord morphogenesis; oxidation-reduction process; positive regulation of gene expression; regulation of gene expression; respiratory system process; somite rostral/caudal axis specification
Reference #:  O70546 (UniProtKB)
Alt. Names/Synonyms: 4lysine (K)-specific demethylase 6A; [histone H3]-trimethyl-L-lysine(27) demethylase 6A; Histone demethylase UTX; Kdm6a; lysine (K)-specific demethylase 6A; Lysine-specific demethylase 6A; OTTMUSP00000018503; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Utx
Gene Symbols: Kdm6a
Molecular weight: 154,355 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene