NCL Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 1 C5|1 43.94 cM
Cellular Component:  cell cortex; cell surface; cytoplasm; cytoplasmic ribonucleoprotein granule; dense fibrillar component; fibrillar center; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  calcium ion binding; DNA binding; DNA topoisomerase binding; ErbB-4 class receptor binding; histone binding; identical protein binding; laminin binding; mRNA 5'-UTR binding; nucleic acid binding; protein binding; protein C-terminus binding; RNA binding; rRNA primary transcript binding; selenocysteine insertion sequence binding; sequence-specific DNA binding; signaling receptor binding; single-stranded DNA binding; telomeric DNA binding
Biological Process:  angiogenesis; cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; endocytosis; negative regulation of apoptotic process; negative regulation of translation; positive regulation of interleukin-6 secretion; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of tumor necrosis factor production; regulation of rRNA processing
Reference #:  P09405 (UniProtKB)
Alt. Names/Synonyms: B530004O11Rik; C23; D0Nds28; D1Nds28; Ncl; Nuc; Nucl; Nucleolin; Protein C23
Gene Symbols: Ncl
Molecular weight: 76,723 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA