Trap100 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 24 family. Ubiquitous. Abundant in skeletal muscle, heart and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11 D|11 62.46 cM
Cellular Component:  mediator complex; nucleus; ubiquitin ligase complex
Molecular Function:  histone acetyltransferase activity; thyroid hormone receptor binding; transcription coactivator activity; transcription coregulator activity
Biological Process:  positive regulation of transcription, DNA-templated; protein heterooligomerization; protein ubiquitination; stem cell population maintenance; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Reference #:  Q99K74 (UniProtKB)
Alt. Names/Synonyms: 911GSE; AU040102; AW547152; D11Ertd307e; DRIP100; genetic suppressor element 2; Gse2; KIAA0130; Med24; Mediator complex subunit 24; Mediator of RNA polymerase II transcription subunit 24; mTRAP100; OTTMUSP00000006776; peroxisome proliferation activation receptor binding protein 2; Pparb2; Pparbp2; R75526; Thrap4; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 100 kDa; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100
Gene Symbols: Med24
Molecular weight: 109,985 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA