Ku70 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding
Chromosomal Location of Human Ortholog: 15 E1|15 38.33 cM
Cellular Component:  chromosome; cytoplasm; Ku70:Ku80 complex; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; transcription factor complex
Molecular Function:  5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; catalytic activity; cyclin binding; damaged DNA binding; DNA binding; double-stranded DNA binding; helicase activity; hydrolase activity; lyase activity; nucleotide binding; protein binding; protein C-terminus binding; protein-containing complex binding; telomeric DNA binding; transcription regulatory region DNA binding
Biological Process:  activation of innate immune response; cellular hyperosmotic salinity response; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to X-ray; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via classical nonhomologous end joining; double-strand break repair via nonhomologous end joining; immune system process; innate immune response; metabolic process; negative regulation of transcription, DNA-templated; positive regulation of neurogenesis; positive regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein heterotetramerization; regulation of smooth muscle cell proliferation; response to ionizing radiation; telomere maintenance; V(D)J recombination
Reference #:  P23475 (UniProtKB)
Alt. Names/Synonyms: 70kDa; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22p1; Ku autoantigen protein p70 homolog; Ku p70; Ku70; thyroid autoantigen 70 kDa; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; Xrcc6
Gene Symbols: Xrcc6
Molecular weight: 69,484 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA