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TFIP11
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. Belongs to the TFP11/STIP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 5|5 F |
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Cellular Component:
catalytic step 2 spliceosome; chromosome, telomeric region; cytoplasm; extracellular matrix; nuclear speck; nucleolus; nucleus; spliceosomal complex; U2-type post-mRNA release spliceosomal complex
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Molecular Function:
nucleic acid binding; protein binding
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Biological Process:
biomineral tissue development; cell differentiation; extracellular matrix organization; mRNA processing; negative regulation of protein binding; negative regulation of protein-containing complex assembly; RNA splicing; spliceosomal complex disassembly
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Reference #:
Q9ERA6
(UniProtKB)
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Alt. Names/Synonyms: 2810002G02Rik; AF097181; AW046167; OTTMUSP00000027457; Septin and tuftelin-interacting protein 1; Srr1; Stip; STIP-1; Tfip11; TFP11; Tip; TIP33; Tip39; tuftelin interacting protein 11; Tuftelin-interacting protein 11; tuftelin-interacting protein 33; Tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD
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Gene Symbols: Tfip11
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Molecular weight:
96,305 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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