TFIP11 Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. Belongs to the TFP11/STIP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  catalytic step 2 spliceosome; chromosome, telomeric region; cytoplasm; extracellular matrix; nuclear speck; nucleolus; nucleus; spliceosomal complex; U2-type post-mRNA release spliceosomal complex
Molecular Function:  nucleic acid binding; protein binding
Biological Process:  biomineral tissue development; cell differentiation; extracellular matrix organization; mRNA processing; negative regulation of protein binding; negative regulation of protein-containing complex assembly; RNA splicing; spliceosomal complex disassembly
Reference #:  Q9ERA6 (UniProtKB)
Alt. Names/Synonyms: 2810002G02Rik; AF097181; AW046167; OTTMUSP00000027457; Septin and tuftelin-interacting protein 1; Srr1; Stip; STIP-1; Tfip11; TFP11; Tip; TIP33; Tip39; tuftelin interacting protein 11; Tuftelin-interacting protein 11; tuftelin-interacting protein 33; Tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD
Gene Symbols: Tfip11
Molecular weight: 96,305 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein