SF3B2 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleus; spliceosomal complex; U12-type spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome
Molecular Function:  protein binding
Biological Process:  mRNA splicing, via spliceosome
Reference #:  Q3UAI4 (UniProtKB)
Alt. Names/Synonyms: 145kD; 145kDa; 2610311M13Rik; 2810441F20Rik; B230398H18Rik; SAP; SAP domain-containing protein; SAP145; SF3b; SF3b1; SF3b14; SF3b145; SF3b15; SF3b150; Sf3b2; splicing factor 3B subunit 2; splicing factor 3b, subunit 2; Uncharacterized protein
Gene Symbols: Sf3b2
Molecular weight: 98,189 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene