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HDAC7
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deacetylase; EC 3.5.1.98; Hydrolase |
| Chromosomal Location of mouse Ortholog: 15|15 F1 |
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Cellular Component:
cytoplasm; cytosol; histone deacetylase complex; nucleus
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Molecular Function:
14-3-3 protein binding; chromatin binding; DNA-binding transcription factor binding; histone deacetylase activity; hydrolase activity; metal ion binding; protein binding; protein kinase binding; protein kinase C binding; protein lysine deacetylase activity; transcription corepressor activity
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Biological Process:
B cell activation; B cell differentiation; cell-cell junction assembly; chromatin organization; histone deacetylation; inflammatory response; negative regulation of DNA-templated transcription; negative regulation of interleukin-2 production; negative regulation of NIK/NF-kappaB signaling; negative regulation of osteoblast differentiation; negative regulation of striated muscle tissue development; negative regulation of transcription by RNA polymerase II; nervous system development; positive regulation of cell migration involved in sprouting angiogenesis; protein deacetylation; vasculogenesis
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Reference #:
Q8C2B3
(UniProtKB)
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Alt. Names/Synonyms: 5830434K02Rik; HD7; HD7a; Hdac; Hdac7; Hdac7a; Histone deacetylase 7; Histone deacetylase 7A; histone deacetylase 7A, promoter 1; histone deacetylase 7A, promoter 2; histone deacetylase 7A, promoter 3; mFLJ00062; mFLJ00062 protein
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Gene Symbols: Hdac7
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Molecular weight:
101,287 Da
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Basal Isoelectric point:
7.11
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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NF-kB Signaling
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Protein Acetylation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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