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RANGAP1
GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export. Belongs to the RNA1 family. Highly expressed in brain, thymus and testis. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of mouse Ortholog: 15 E1|15 38.21 cM |
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Cellular Component:
aggresome; axon cytoplasm; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic periphery of the nuclear pore complex; cytoskeleton; cytosol; dendrite; intracellular membrane-bounded organelle; kinetochore; mitotic spindle; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nucleus; perinuclear region of cytoplasm; SUMO ligase complex
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Molecular Function:
GTPase activator activity; RNA binding; small GTPase binding; ubiquitin protein ligase binding
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Biological Process:
activation of GTPase activity; cellular response to peptide hormone stimulus; negative regulation of protein export from nucleus; nuclear export; nucleocytoplasmic transport; protein sumoylation; signal transduction
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Reference #:
P46061
(UniProtKB)
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Alt. Names/Synonyms: C79654; Fug1; mKIAA1835; RAGP1; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Rangap1; Rangap1 protein
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Gene Symbols: Rangap1
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Molecular weight:
63,531 Da
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Basal Isoelectric point:
4.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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