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RANGAP1
a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9). Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of Human Ortholog: 15 E1|15 38.21 cM |
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Cellular Component:
aggresome; axon cytoplasm; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic periphery of the nuclear pore complex; cytoskeleton; cytosol; dendrite; intracellular membrane-bounded organelle; mitotic spindle; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nucleus; perinuclear region of cytoplasm
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Molecular Function:
GTPase activator activity; Ran GTPase binding; RNA binding; ubiquitin protein ligase binding
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Biological Process:
activation of GTPase activity; cellular response to peptide hormone stimulus; negative regulation of protein export from nucleus; signal transduction
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Reference #:
P46061
(UniProtKB)
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Alt. Names/Synonyms: C79654; Fug1; mKIAA1835; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Rangap1; Rangap1 protein
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Gene Symbols: Rangap1
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Molecular weight:
63,531 Da
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Basal Isoelectric point:
4.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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