RANGAP1 a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9). Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 15 E1|15 38.21 cM
Cellular Component:  aggresome; axon cytoplasm; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic periphery of the nuclear pore complex; cytoskeleton; cytosol; dendrite; intracellular membrane-bound organelle; kinetochore; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nucleus; perinuclear region of cytoplasm
Molecular Function:  GTPase activator activity; Ran GTPase binding; RNA binding; ubiquitin protein ligase binding
Biological Process:  cellular response to peptide hormone stimulus; negative regulation of protein export from nucleus; signal transduction
Reference #:  P46061 (UniProtKB)
Alt. Names/Synonyms: C79654; Fug1; mKIAA1835; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Rangap1; Rangap1 protein
Gene Symbols: Rangap1
Molecular weight: 63,531 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RANGAP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene