RANGAP1 GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export. Belongs to the RNA1 family. Highly expressed in brain, thymus and testis. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of mouse Ortholog: 15 E1|15 38.21 cM
Cellular Component:  aggresome; axon cytoplasm; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic periphery of the nuclear pore complex; cytoskeleton; cytosol; dendrite; intracellular membrane-bounded organelle; kinetochore; mitotic spindle; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nucleus; perinuclear region of cytoplasm; SUMO ligase complex
Molecular Function:  GTPase activator activity; RNA binding; small GTPase binding; ubiquitin protein ligase binding
Biological Process:  activation of GTPase activity; cellular response to peptide hormone stimulus; negative regulation of protein export from nucleus; nuclear export; nucleocytoplasmic transport; protein sumoylation; signal transduction
Reference #:  P46061 (UniProtKB)
Alt. Names/Synonyms: C79654; Fug1; mKIAA1835; RAGP1; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Rangap1; Rangap1 protein
Gene Symbols: Rangap1
Molecular weight: 63,531 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene