RAD18 E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. Belongs to the RAD18 family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 6|6 E3
Cellular Component:  centrosome; chromatin; cytoplasm; cytoskeleton; nuclear body; nuclear inclusion body; nucleoplasm; nucleus; Rad6-Rad18 complex; replication fork; site of double-strand break; XY body
Molecular Function:  DNA binding; identical protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein-containing complex binding; single-stranded DNA binding; single-stranded DNA-dependent ATPase activity; transferase activity; ubiquitin protein ligase activity; ubiquitin protein ligase binding; Y-form DNA binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; negative regulation of cell death; negative regulation of DNA recombination; positive regulation of chromosome segregation; postreplication repair; protein autoubiquitination; protein monoubiquitination; response to UV; spermatogenesis
Reference #:  Q9QXK2 (UniProtKB)
Alt. Names/Synonyms: 2810024C04Rik; E3 ubiquitin-protein ligase RAD18; mRAD18Sc; OTTMUSP00000018917; post-replication repair protein RAD18SC; Postreplication repair protein RAD18; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); Rad18sc; RING-type E3 ubiquitin transferase RAD18
Gene Symbols: Rad18
Molecular weight: 57,412 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
Select Structure to View Below

RAD18

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene