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RAD18
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. Belongs to the RAD18 family. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 6|6 E3 |
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Cellular Component:
centrosome; chromatin; cytoplasm; cytoskeleton; male germ cell nucleus; nuclear body; nuclear inclusion body; nucleoplasm; nucleus; Rad6-Rad18 complex; replication fork; site of double-strand break; XY body
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Molecular Function:
DNA binding; identical protein binding; metal ion binding; molecular function inhibitor activity; polyubiquitin modification-dependent protein binding; protein binding; protein-containing complex binding; single-stranded DNA binding; transferase activity; ubiquitin protein ligase activity; ubiquitin protein ligase binding; Y-form DNA binding
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Biological Process:
DNA damage response; DNA repair; negative regulation of DNA recombination; positive regulation of chromosome segregation; postreplication repair; protein autoubiquitination; protein monoubiquitination; response to UV; spermatogenesis
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Reference #:
Q9QXK2
(UniProtKB)
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Alt. Names/Synonyms: 2810024C04Rik; E3 ubiquitin-protein ligase RAD18; mRAD18Sc; OTTMUSP00000018917; post-replication repair protein RAD18SC; Postreplication repair protein RAD18; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); Rad18sc; RING-type E3 ubiquitin transferase RAD18
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Gene Symbols: Rad18
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Molecular weight:
57,412 Da
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Basal Isoelectric point:
6.89
Predict pI for various phosphorylation states
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