|
CCNL1
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Belongs to the cyclin family. Cyclin L subfamily. Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; Oncoprotein |
| Chromosomal Location of Human Ortholog: 3|3 E1 |
|
Cellular Component:
cytoplasm; nuclear speck; nucleus; transcription elongation factor complex
|
|
Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity; protein binding
|
|
Biological Process:
regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; RNA processing
|
|
Reference #:
Q52KE7
(UniProtKB)
|
|
Alt. Names/Synonyms: 2610030E23Rik; ania-6a; Ania6a; AU018493; Ccn1; Ccnl; Ccnl1; Cyclin Ania-6a; cyclin L1; Cyclin-L; Cyclin-L1
|
|
Gene Symbols: Ccnl1
|
|
Molecular weight:
60,133 Da
|
|
Basal Isoelectric point:
10.71
Predict pI for various phosphorylation states
|
