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CCNL1
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Belongs to the cyclin family. Cyclin L subfamily. Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 3|3 E1 |
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Cellular Component:
cyclin-dependent protein kinase holoenzyme complex; cytoplasm; nuclear speck; nucleus; transcription elongation factor complex
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Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity; protein binding
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Biological Process:
regulation of apoptotic process; regulation of cell cycle; regulation of centrosome cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA-templated transcription; regulation of RNA splicing; regulation of transcription by RNA polymerase II; RNA processing
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Reference #:
Q52KE7
(UniProtKB)
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Alt. Names/Synonyms: 2610030E23Rik; ania-6a; Ania6a; AU018493; Ccn1; Ccnl; Ccnl1; Cyclin Ania-6a; cyclin L1; Cyclin-L; Cyclin-L1
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Gene Symbols: Ccnl1
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Molecular weight:
60,133 Da
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Basal Isoelectric point:
10.71
Predict pI for various phosphorylation states
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