EPS15R Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 8|8 B3.3
Cellular Component:  clathrin coat of coated pit; clathrin-coated pit; membrane; nucleus; plasma membrane
Molecular Function:  calcium ion binding; metal ion binding; protein binding
Biological Process:  endocytosis
Reference #:  Q60902 (UniProtKB)
Alt. Names/Synonyms: 9830147J04Rik; AI593686; EP15R; epidermal growth factor receptor pathway substrate 15, related sequence; epidermal growth factor receptor pathway substrate 15-like 1; Epidermal growth factor receptor pathway substrate 15-related sequence; Epidermal growth factor receptor substrate 15-like 1; Eps; Eps1; Eps15-related protein; Eps15-rs; Eps15l1; Eps15R
Gene Symbols: Eps15l1
Molecular weight: 99,309 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein