EPS15R epidermal growth factor receptor substrate protein 15R. Contains three EH domains which are implicated in endocytosis, vesicle transport and signal transduction. All three EH domains contain calcium-binding domains ofthe EF-hand type. Contains 2 UIM motifs, which are is responsible for ubiquitin recognition and monoubiquitination. May function as an adaptor between ubiquitinated proteins and the clathrin coat or other endocytic scaffolds. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 8|8 B3.3
Cellular Component:  clathrin coat of coated pit; clathrin-coated pit; membrane; nucleus; plasma membrane
Molecular Function:  calcium ion binding; metal ion binding; protein binding
Biological Process:  endocytosis
Reference #:  Q60902 (UniProtKB)
Alt. Names/Synonyms: 9830147J04Rik; AI593686; EP15R; epidermal growth factor receptor pathway substrate 15, related sequence; epidermal growth factor receptor pathway substrate 15-like 1; Epidermal growth factor receptor pathway substrate 15-related sequence; Epidermal growth factor receptor substrate 15-like 1; Eps15-related protein; Eps15-rs; Eps15l1; Eps15R
Gene Symbols: Eps15l1
Molecular weight: 99,309 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
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EPS15R

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein