DBF4 Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Highly expressed in testis and thymus. Expressed also in most cancer cells lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 5|5 A1
Cellular Component:  Dbf4-dependent protein kinase complex; nuclear body; nucleus
Molecular Function:  metal ion binding; nucleic acid binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; zinc ion binding
Biological Process:  cell cycle; DNA replication; positive regulation of nuclear cell cycle DNA replication; regulation of cell cycle phase transition; traversing start control point of mitotic cell cycle
Reference #:  Q9QZ41 (UniProtKB)
Alt. Names/Synonyms: AA545217; activator of S phase kinase; Ask; Dbf4; DBF4 homolog; DBF4 homolog (S. cerevisiae); DBF4 zinc finger; Dbf4a; MuDBF4; Protein DBF4 homolog A
Gene Symbols: Dbf4
Molecular weight: 74,176 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene