BAP1 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. Belongs to the peptidase C12 family. BAP1 subfamily. Highly expressed in testis, placenta and ovary. Expressed in breast. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; PR-DUB complex
Molecular Function:  chromatin binding; cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  chromatin organization; macrophage homeostasis; monoubiquitinated histone H2A deubiquitination; monoubiquitinated protein deubiquitination; negative regulation of cell proliferation; negative regulation of transcription, DNA-templated; protein deubiquitination; protein K48-linked deubiquitination; regulation of cell cycle; regulation of cell growth; regulation of cytokine production involved in inflammatory response; regulation of inflammatory response; response to inorganic substance; ubiquitin-dependent protein catabolic process
Reference #:  Q99PU7 (UniProtKB)
Alt. Names/Synonyms: 2300006C11Rik; AA989761; AW553466; Bap1; Brca1 associated protein 1; BRCA1-associated protein 1; Kiaa0272; mKIAA0272; Ubiquitin C-terminal hydrolase X4; Ubiquitin carboxyl-terminal hydrolase BAP1; UCH-X4
Gene Symbols: Bap1
Molecular weight: 80,492 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene