SSB
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Note: This description may include information from UniProtKB.
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Protein type: Transcription initiation complex |
Chromosomal Location of human Ortholog: 2q31.1 |
Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; nucleus; ribonucleoprotein complex
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Molecular Function:
DNA binding; mRNA binding; poly(U) RNA binding; protein binding; RNA binding; sequence-specific mRNA binding; tRNA binding
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Biological Process:
histone mRNA metabolic process; IRES-dependent viral translational initiation; nuclear histone mRNA catabolic process; positive regulation of translation; protein localization to cytoplasmic stress granule; tRNA 3'-end processing; tRNA 5'-leader removal; tRNA export from nucleus; tRNA modification; tRNA processing
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Reference #:
P05455
(UniProtKB)
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Alt. Names/Synonyms: autoantigen La; La; La autoantigen; La ribonucleoprotein; La ribonucleoprotein domain family, member 3; La/SSB; LARP3; lupus La antigen; Lupus La protein; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B; Sjogren syndrome antigen B (autoantigen La); small RNA binding exonuclease protection factor La; SS-B; SS-B/La protein; SSB
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Gene Symbols: SSB
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Molecular weight:
46,837 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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