HDAC7 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 12q13.11
Cellular Component:  cytoplasm; cytosol; histone deacetylase complex; nucleoplasm; nucleus
Molecular Function:  14-3-3 protein binding; activating transcription factor binding; chromatin binding; metal ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); protein binding; protein kinase binding; protein kinase C binding; repressing transcription factor binding; transcription corepressor activity
Biological Process:  cell-cell junction assembly; histone H3 deacetylation; negative regulation of interleukin-2 production; negative regulation of NIK/NF-kappaB signaling; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cell migration involved in sprouting angiogenesis; vasculogenesis
Reference #:  Q8WUI4 (UniProtKB)
Alt. Names/Synonyms: DKFZp586J0917; FLJ99588; HD7; HD7a; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A
Gene Symbols: HDAC7
Molecular weight: 102,927 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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