OTUD5 Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Belongs to the peptidase C85 family. Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease
Chromosomal Location of human Ortholog: Xp11.23
Cellular Component:  cytosol
Molecular Function:  Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity
Biological Process:  negative regulation of type I interferon production; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; response to lipopolysaccharide
Disease: Multiple Congenital Anomalies-neurodevelopmental Syndrome, X-linked
Reference #:  Q96G74 (UniProtKB)
Alt. Names/Synonyms: deubiquinating enzyme A; Deubiquitinating enzyme A; DKFZp761A052; DUBA; MGC104871; OTU deubiquitinase 5; OTU domain containing 5; OTU domain-containing protein 5; OTUD5
Gene Symbols: OTUD5
Molecular weight: 60,626 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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OTUD5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein