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NAF1
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Belongs to the NAF1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 4q32.2 |
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Cellular Component:
cytoplasm; nucleoplasm; sno(s)RNA-containing ribonucleoprotein complex
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Molecular Function:
identical protein binding; protein binding; RNA binding; telomerase RNA binding
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Biological Process:
box H/ACA snoRNP assembly; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomere lengthening; ribosome biogenesis; RNA stabilization; snoRNA guided rRNA pseudouridine synthesis; telomerase holoenzyme complex assembly; telomerase RNA stabilization
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Disease: Pulmonary Fibrosis And/or Bone Marrow Failure Syndrome, Telomere-related, 7
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Reference #:
Q96HR8
(UniProtKB)
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Alt. Names/Synonyms: H/ACA ribonucleoprotein complex non-core subunit NAF1; hNAF1; NAF1; nuclear assembly factor 1 homolog; nuclear assembly factor 1 homolog (S. cerevisiae); nuclear assembly factor 1 ribonucleoprotein
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Gene Symbols: NAF1
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Molecular weight:
53,717 Da
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Basal Isoelectric point:
4.76
Predict pI for various phosphorylation states
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