NAF1 RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Belongs to the NAF1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 4q32.2
Cellular Component:  cytoplasm; nucleus; small nucleolar ribonucleoprotein complex
Molecular Function:  protein binding; RNA binding; telomerase RNA binding
Biological Process:  box H/ACA snoRNP assembly; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomere lengthening; ribosome biogenesis; RNA stabilization; snoRNA guided rRNA pseudouridine synthesis; telomerase holoenzyme complex assembly; telomerase RNA stabilization
Reference #:  Q96HR8 (UniProtKB)
Alt. Names/Synonyms: H/ACA ribonucleoprotein complex non-core subunit NAF1; hNAF1; NAF1; nuclear assembly factor 1 homolog (S. cerevisiae)
Gene Symbols: NAF1
Molecular weight: 53,717 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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