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URG4
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family. Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 7p13 |
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Cellular Component:
cytosol; nucleus
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Molecular Function:
GTP binding
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Biological Process:
cell cycle
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Reference #:
Q8TCY9
(UniProtKB)
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Alt. Names/Synonyms: DKFZp666G166; DKFZp686O0457; HBV X protein up-regulated gene 4 protein; HBxAg up-regulated gene 4 protein; KIAA1507; up-regulated gene 4; Up-regulator of cell proliferation; upregulator of cell proliferation; URG4; URGCP
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Gene Symbols: URGCP
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Molecular weight:
104,987 Da
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Basal Isoelectric point:
6
Predict pI for various phosphorylation states
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