PPP4R2 Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Belongs to the PPP4R2 family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 3p13
Cellular Component:  centrosome; nucleoplasm; nucleus; protein phosphatase 4 complex
Molecular Function:  protein binding; protein binding, bridging; protein phosphatase regulator activity
Biological Process:  cellular protein modification process; mRNA processing; regulation of double-strand break repair via homologous recombination; regulation of phosphoprotein phosphatase activity; RNA splicing
Reference #:  Q9NY27 (UniProtKB)
Alt. Names/Synonyms: MGC131930; PP4R2; PPP4R2; protein phosphatase 4 regulatory subunit 2; protein phosphatase 4, regulatory subunit 2; Serine/threonine-protein phosphatase 4 regulatory subunit 2
Gene Symbols: PPP4R2
Molecular weight: 46,898 Da
Basal Isoelectric point: 4.48  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene