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PPP4R2
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Belongs to the PPP4R2 family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 3p13 |
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Cellular Component:
centrosome; chromatin; cytoplasm; nucleoplasm; nucleus; protein phosphatase 4 complex
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Molecular Function:
protein binding; protein phosphatase regulator activity; protein-macromolecule adaptor activity
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Biological Process:
mRNA processing; protein modification process; regulation of double-strand break repair; regulation of double-strand break repair via homologous recombination; RNA splicing
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Reference #:
Q9NY27
(UniProtKB)
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Alt. Names/Synonyms: MGC131930; PP4R2; PPP4R2; protein phosphatase 4 regulatory subunit 2; protein phosphatase 4, regulatory subunit 2; Serine/threonine-protein phosphatase 4 regulatory subunit 2
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Gene Symbols: PPP4R2
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Molecular weight:
46,898 Da
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Basal Isoelectric point:
4.48
Predict pI for various phosphorylation states
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