DCP1A Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Belongs to the DCP1 family. Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nucleus; P-body
Molecular Function:  enzyme activator activity; hydrolase activity; identical protein binding; kinesin binding; protein binding
Biological Process:  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; protein localization to cytoplasmic stress granule; regulation of mRNA stability
Reference #:  Q9NPI6 (UniProtKB)
Alt. Names/Synonyms: DCP1 decapping enzyme homolog A; DCP1 decapping enzyme homolog A (S. cerevisiae); DCP1 decapping enzyme-like protein A; DCP1A; decapping enzyme hDcp1a; decapping mRNA 1A; FLJ21691; HSA275986; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF
Gene Symbols: DCP1A
Molecular weight: 63,278 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene