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USP16
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Belongs to the peptidase C19 family. USP16 subfamily. Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: 21q21.3 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; histone binding; histone H2A deubiquitinase activity; ribosomal small subunit binding; transcription coactivator activity; ubiquitin binding; zinc ion binding
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Biological Process:
cell division; chromatin remodeling; DNA damage response; histone deubiquitination; mitotic nuclear division; monoubiquitinated protein deubiquitination; positive regulation of DNA-templated transcription; positive regulation of ribosome biogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of translational elongation; protein deubiquitination; protein homotetramerization; regulation of cell cycle; regulation of transcription by RNA polymerase II; ubiquitin-dependent protein catabolic process
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Reference #:
Q9Y5T5
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme 16; Ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific peptidase 16; ubiquitin specific protease 16; Ubiquitin thioesterase 16; ubiquitin thiolesterase 16; Ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; Ubiquitin-specific-processing protease 16; UBP-M; UBP16; UBPM; USP16
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Gene Symbols: USP16
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Molecular weight:
93,570 Da
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Basal Isoelectric point:
6.5
Predict pI for various phosphorylation states
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