SF3B1 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the SF3B1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U11/U12 snRNP; U12-type spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome
Molecular Function:  protein binding
Biological Process:  mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; RNA splicing, via transesterification reactions; spliceosomal complex assembly
Disease: Myelodysplastic Syndrome
Reference #:  O75533 (UniProtKB)
Alt. Names/Synonyms: Hsh155; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3B1; SF3b155; spliceosome associated protein 155; Spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155kDa
Gene Symbols: SF3B1
Molecular weight: 145,830 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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