PFKP Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other
Chromosomal Location of Human Ortholog: 10p15.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  6-phosphofructokinase activity; metal ion binding; protein-containing complex binding
Biological Process:  canonical glycolysis; cellular response to leukemia inhibitory factor
Reference #:  Q01813 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructokinase type C; 6-phosphofructokinase, platelet type; ATP-dependent 6-phosphofructokinase, platelet type; FLJ40226; K6PP; PFK-C; PFKF; PFKP; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphofructokinase, platelet type; Phosphohexokinase
Gene Symbols: PFKP
Molecular weight: 85,596 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PFKP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene