NCL Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  cell cortex; cytoplasmic ribonucleoprotein granule; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  DNA topoisomerase binding; identical protein binding; mRNA 5'-UTR binding; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding
Biological Process:  angiogenesis; cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; negative regulation of translation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
Reference #:  P19338 (UniProtKB)
Alt. Names/Synonyms: C23; FLJ45706; FLJ59041; NCL; Nsr1; NUCL; Nucleolin; Protein C23
Gene Symbols: NCL
Molecular weight: 76,614 Da
Basal Isoelectric point: 4.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA