|
NCL
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding |
| Chromosomal Location of human Ortholog: 2q37.1 |
|
Cellular Component:
cell cortex; chromosome; cornified envelope; cytoplasmic ribonucleoprotein granule; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex
|
|
Molecular Function:
DNA topoisomerase binding; identical protein binding; insulin receptor substrate binding; mRNA 5'-UTR binding; PH domain binding; protein binding; RNA binding; telomeric DNA binding
|
|
Biological Process:
angiogenesis; cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of peptidyl-tyrosine phosphorylation
|
|
Reference #:
P19338
(UniProtKB)
|
|
Alt. Names/Synonyms: C23; FLJ45706; FLJ59041; NCL; Nsr1; NUCL; Nucleolin; Protein C23
|
|
Gene Symbols: NCL
|
|
Molecular weight:
76,614 Da
|
|
Basal Isoelectric point:
4.6
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
