MCM2 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. Belongs to the MCM family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC
Chromosomal Location of human Ortholog: 3q21.3
Cellular Component:  chromatin; cytoplasm; MCM complex; microtubule cytoskeleton; nuclear origin of replication recognition complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA replication origin binding; enzyme binding; helicase activity; histone binding; metal ion binding; protein binding
Biological Process:  apoptotic process; cellular response to interleukin-4; cochlea development; DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; G1/S transition of mitotic cell cycle; negative regulation of DNA helicase activity; nucleosome assembly
Disease: Deafness, Autosomal Dominant 70
Reference #:  P49736 (UniProtKB)
Alt. Names/Synonyms: BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; DFNA70; DNA replication licensing factor MCM2; KIAA0030; MCM2; MCM2 minichromosome maintenance deficient 2, mitotin; MGC10606; minichromosome maintenance complex component 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; MITOTIN; Nuclear protein BM28
Gene Symbols: MCM2
Molecular weight: 101,896 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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