TLE3 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Belongs to the WD repeat Groucho/TLE family. Placenta and lung. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q23
Cellular Component:  beta-catenin-TCF complex; nucleoplasm
Molecular Function:  protein binding
Biological Process:  animal organ morphogenesis; beta-catenin-TCF complex assembly; negative regulation of cold-induced thermogenesis; negative regulation of nucleic acid-templated transcription; regulation of transcription, DNA-templated; signal transduction; Wnt signaling pathway
Reference #:  Q04726 (UniProtKB)
Alt. Names/Synonyms: enhancer of split groucho 3; Enhancer of split groucho-like protein 3; ESG; ESG3; FLJ39460; GRG3; HsT18976; KIAA1547; TLE family member 3, transcriptional corepressor; TLE3; transducin like enhancer of split 3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3, homolog of Drosophila E(sp1); Transducin-like enhancer protein 3
Gene Symbols: TLE3
Molecular weight: 83,417 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein