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TLE3
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Belongs to the WD repeat Groucho/TLE family. Placenta and lung. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 15q23 |
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Cellular Component:
beta-catenin-TCF complex; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
protein binding; transcription corepressor activity
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Biological Process:
animal organ morphogenesis; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of DNA-templated transcription; signal transduction; Wnt signaling pathway
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Reference #:
Q04726
(UniProtKB)
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Alt. Names/Synonyms: enhancer of split groucho 3; Enhancer of split groucho-like protein 3; ESG; ESG3; FLJ39460; GRG3; HsT18976; KIAA1547; TLE family member 3, transcriptional corepressor; TLE3; transducin like enhancer of split 3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3, homolog of Drosophila E(sp1); Transducin-like enhancer protein 3
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Gene Symbols: TLE3
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Molecular weight:
83,417 Da
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Basal Isoelectric point:
6.72
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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