EPS15R iso2 Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component:  clathrin coat of coated pit; cytosol; nucleus; plasma membrane
Molecular Function:  calcium ion binding; protein binding
Biological Process:  endocytosis; membrane organization; negative regulation of epidermal growth factor receptor signaling pathway
Reference #:  Q9UBC2-2 (UniProtKB)
Alt. Names/Synonyms: EP15R; epidermal growth factor receptor pathway substrate 15-like 1; Epidermal growth factor receptor substrate 15-like 1; epidermal growth factor receptor substrate EPS15R; Eps15-related protein; EPS15L1; EPS15R
Gene Symbols: EPS15L1
Molecular weight: 99,606 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
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EPS15R iso2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein