DBF4 DBF4 a regulatory subunit of the cell-cycle and genome duplication kinase Cdc7. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. Its expression varies during the cell cycle: it is low in G1, increases during G1-S, and remains high during S and G2-M. Cdc7- DBF4B interacts physically with Mcm2 and phosphorylates Mcm2 and three other members of the Mcm family. Has a postreplicative function in meiosis. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 7q21.12
Cellular Component:  nuclear body; nucleoplasm; nucleus
Molecular Function:  enzyme activator activity; nucleic acid binding; protein binding; zinc ion binding
Biological Process:  DNA replication; G1/S transition of mitotic cell cycle; positive regulation of protein serine/threonine kinase activity
Reference #:  Q9UBU7 (UniProtKB)
Alt. Names/Synonyms: Activator of S phase kinase; ASK; CHIF; Chiffon homolog A; DBF4; DBF4 homolog (S. cerevisiae); DBF4-type zinc finger-containing protein 1; DBF4A; Protein DBF4 homolog A; ZDBF1; zinc finger, DBF-type containing 1
Gene Symbols: DBF4
Molecular weight: 76,858 Da
Basal Isoelectric point: 8.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene