DAB2 an adaptor protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Involved in several receptor-mediated signaling pathways. Required for recycling of the TGF-beta receptor. Involved in endocytosis of CFTR and of megalin/LRP2 lipoprotein receptor during embryonal development. Interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Three alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Tumor suppressor
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component:  clathrin-coated pit; clathrin-coated vesicle; clathrin-coated vesicle membrane; cytosol; fibrillar center; intracellular membrane-bounded organelle; lysosomal membrane; plasma membrane
Molecular Function:  cargo receptor activity; clathrin adaptor activity; protein binding; protein C-terminus binding; SMAD binding
Biological Process:  apoptotic process; leading edge cell differentiation; membrane organization; multicellular organism development; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of protein binding; negative regulation of protein localization to plasma membrane; negative regulation of transcription, DNA-templated; positive regulation of cell migration; positive regulation of clathrin-dependent endocytosis; positive regulation of early endosome to late endosome transport; positive regulation of endocytosis; positive regulation of epithelial to mesenchymal transition; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; protein transport; receptor-mediated endocytosis; Wnt signaling pathway
Reference #:  P98082 (UniProtKB)
Alt. Names/Synonyms: Adaptor molecule disabled-2; DAB adaptor protein 2; Dab, mitogen-responsive phosphoprotein, homolog 2; DAB2; DAB2, clathrin adaptor protein; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626; mitogen-responsive phosphoprotein
Gene Symbols: DAB2
Molecular weight: 82,448 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DAB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB