an adaptor protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Involved in several receptor-mediated signaling pathways. Required for recycling of the TGF-beta receptor. Involved in endocytosis of CFTR and of megalin/LRP2 lipoprotein receptor during embryonal development. Interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Three alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Molecular Function: cargo receptor activity; clathrin adaptor activity; protein binding; protein C-terminus binding; SMAD binding
Biological Process: apoptotic process; leading edge cell differentiation; membrane organization; multicellular organism development; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of protein binding; negative regulation of protein localization to plasma membrane; negative regulation of transcription, DNA-templated; positive regulation of cell migration; positive regulation of clathrin-dependent endocytosis; positive regulation of early endosome to late endosome transport; positive regulation of endocytosis; positive regulation of epithelial to mesenchymal transition; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; protein transport; receptor-mediated endocytosis; Wnt signaling pathway