ZNF148 a transcription factor. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3q21.2
Cellular Component:  Golgi apparatus; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  cellular defense response; gamete generation; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; protein-containing complex assembly; transcription by RNA polymerase II
Disease: Global Developmental Delay, Absent Or Hypoplastic Corpus Callosum, And Dysmorphic Facies
Reference #:  Q9UQR1 (UniProtKB)
Alt. Names/Synonyms: BERF-1; BFCOL1; CACCC box-binding protein; CLL-associated antigen KW-10; GDACCF; HT-BETA; pHZ-52; Transcription factor ZBP-89; ZBP-89; ZBP89; ZFP148; Zinc finger DNA-binding protein 89; Zinc finger protein 148; ZN148; ZNF148
Gene Symbols: ZNF148
Molecular weight: 88,976 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene