UTX Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Belongs to the UTX family. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of human Ortholog: Xp11.3
Cellular Component:  histone methyltransferase complex; MLL3/4 complex; nucleoplasm; nucleus
Molecular Function:  dioxygenase activity; identical protein binding; metal ion binding
Biological Process:  canonical Wnt signaling pathway; cardiovascular system development; chromatin remodeling; heart morphogenesis; histone H3-K27 demethylation; histone H3-K4 methylation; in utero embryonic development; mesodermal cell differentiation; multicellular organism growth; neural tube closure; notochord morphogenesis; oxidation-reduction process; positive regulation of gene expression; respiratory system process; somite rostral/caudal axis specification
Disease: Kabuki Syndrome 1; Kabuki Syndrome 2
Reference #:  O15550 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(27) demethylase 6A; bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); DKFZp686A03225; Histone demethylase UTX; KABUK2; KDM6A; lysine (K)-specific demethylase 6A; lysine demethylase 6A; Lysine-specific demethylase 6A; MGC141941; ubiquitously transcribed tetratricopeptide repeat protein X-linked; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; UTX
Gene Symbols: KDM6A
Molecular weight: 154,177 Da
Basal Isoelectric point: 7.17  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UTX

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene