USP7 an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component:  chromosome; cytosol; nucleoplasm; nucleus; PML body; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; Lys48-specific deubiquitinase activity; p53 binding; protein binding; protein C-terminus binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitinyl hydrolase activity
Biological Process:  histone H2B conserved C-terminal lysine deubiquitination; maintenance of DNA methylation; monoubiquitinated protein deubiquitination; multicellular organism development; negative regulation of NF-kappaB transcription factor activity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of DNA demethylation; protein deubiquitination; protein K48-linked deubiquitination; protein stabilization; protein ubiquitination; regulation of circadian rhythm; regulation of DNA-binding transcription factor activity; regulation of protein stability; regulation of telomere capping; rhythmic process; transcription-coupled nucleotide-excision repair; ubiquitin-dependent protein catabolic process; viral process
Reference #:  Q93009 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 7; HAUSP; Herpes virus-associated ubiquitin-specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF1; Ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; UBP7; USP7
Gene Symbols: USP7
Molecular weight: 128,302 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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USP7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB